Dopamine receptor agonists in cardiovascular medicine

P T Horn; M B Murphy

doi:10.1016/1050-1738(91)90002-V

Dopamine receptor agonists in cardiovascular medicine

Trends Cardiovasc Med. 1991 Apr;1(3):103-7. doi: 10.1016/1050-1738(91)90002-V.

Authors

P T Horn¹, M B Murphy

Affiliation

¹ The Committee on Clinical Pharmacology in the Departments of Pharmacological and Physiological Sciences, Medicine and Pediatrics, University of Chicago, Chicago, IL 60637 USA.

PMID: 21239323
DOI: 10.1016/1050-1738(91)90002-V

Abstract

The cardiovascular and renal effects of dopamine are mediated through peripheral catecholamine receptors. Knowledge of the receptor type responsible for each of the actions of dopamine leads to its rational use clinically and to understanding the hemodynamic actions of the newer dopamine receptor agonists recently introduced into clinical trials. Several of the newer agonists have profiles of receptor activities that differ from dopamine, and early clinical studies indicate that they will have different therapeutic indications and applications.