Are polycomb group bodies gene silencing factories?

Jacob W Hodgson; Hugh W Brock

doi:10.1016/j.cell.2011.01.006

Are polycomb group bodies gene silencing factories?

Cell. 2011 Jan 21;144(2):170-1. doi: 10.1016/j.cell.2011.01.006.

Authors

Jacob W Hodgson¹, Hugh W Brock

Affiliation

¹ Department of Zoology, University of British Columbia, Vancouver BC, Canada.

PMID: 21241887
DOI: 10.1016/j.cell.2011.01.006

Abstract

Polycomb group (PcG) proteins mediate long-range associations between Hox genes, which correlate with gene repression in vivo. Bantignies et al. (2011) identify a physiological role for the nuclear localization of Hox genes in PcG-mediated gene silencing, strengthening the evidence that nuclear positioning regulates gene expression.

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