GABA withdrawal syndrome: a model of the epilepsia partialis continua

Jpn J Psychiatry Neurol. 1990 Jun;44(2):438-9.

Abstract

After the chronic infusion of GABA into the cortex of baboon Papio Papio, a sudden stop of the infusion provoked cortical epileptic discharges around the infused area. And the baboon exhibited partial epilepsy for about 3 days. The result suggested that GABA withdrawal syndrome should be a good model not only to understand the mechanism of epilepsia partialis continua but also partial epilepsy with a circumscribed cortical focus.

MeSH terms

  • Animals
  • Cerebral Cortex / drug effects*
  • Electroencephalography / drug effects*
  • Epilepsies, Partial / chemically induced*
  • Evoked Potentials / drug effects
  • Male
  • Neural Inhibition / drug effects*
  • Papio
  • Status Epilepticus / chemically induced*
  • Substance Withdrawal Syndrome / physiopathology*
  • gamma-Aminobutyric Acid / toxicity*

Substances

  • gamma-Aminobutyric Acid