Abstract
A series of 18 novel 2-hydrazolyl-4-thiazolidinones-5-carboxylic acids, amides and 5,6-α,β-unsaturated esters were synthesized, and their in vitro activity on cruzipain and T. cruzi epimastigotes was determined. Some agents show activity at 37 μm concentration in the enzyme assay. Computational tools and docking were used to correlate the biological response with the physicochemical parameters of the compounds and their cruzipain inhibitory effects.
© 2011 John Wiley & Sons A/S.
Publication types
-
Research Support, N.I.H., Extramural
MeSH terms
-
Acetamides / chemical synthesis
-
Acetamides / chemistry
-
Acetamides / toxicity
-
Animals
-
Antiprotozoal Agents / chemical synthesis*
-
Antiprotozoal Agents / chemistry
-
Antiprotozoal Agents / toxicity
-
Binding Sites
-
Catalytic Domain
-
Chlorocebus aethiops
-
Computer Simulation
-
Cysteine Endopeptidases / chemistry
-
Cysteine Endopeptidases / metabolism
-
Protozoan Proteins
-
Quantitative Structure-Activity Relationship
-
Thiazolidines / chemistry*
-
Trypanosoma cruzi / drug effects*
-
Trypanosoma cruzi / enzymology
-
Vero Cells
Substances
-
Acetamides
-
Antiprotozoal Agents
-
Protozoan Proteins
-
Thiazolidines
-
acetamide
-
Cysteine Endopeptidases
-
cruzipain