Abstract
The Polycomb (PcG) and Trithorax (TrxG) group proteins are essential for development in all multicellular organisms. Mutations of the PcG and TrxG genes act as early embryonic lethals, while their overexpression correlates with malignancies. Comparative genome analysis showed that PcG and TrxG form a binary regulatory system that functions as an epigenetic rheostat to determine the threshold levels of extracellular signals affecting the expression levels of key developmental genes.
MeSH terms
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Animals
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Chromatin / genetics
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Chromatin / metabolism*
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Chromosomal Proteins, Non-Histone / genetics
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Chromosomal Proteins, Non-Histone / metabolism*
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Drosophila Proteins / genetics
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Drosophila Proteins / metabolism*
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Drosophila melanogaster
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Epigenesis, Genetic / physiology*
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Gene Expression Regulation, Developmental / physiology*
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Genome-Wide Association Study
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Polycomb Repressive Complex 1
Substances
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Chromatin
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Chromosomal Proteins, Non-Histone
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Drosophila Proteins
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Pc protein, Drosophila
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trx protein, Drosophila
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Polycomb Repressive Complex 1