Interaction of ACE and CYP11B2 genes on blood pressure response to hydrochlorothiazide in Han Chinese hypertensive patients

Clin Exp Hypertens. 2011;33(3):141-6. doi: 10.3109/10641963.2010.531838. Epub 2011 Jan 26.

Abstract

To valuate whether angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and aldosterone synthase (CYP11B2) gene -344T/C polymorphism are associated with individual response to hydrochlorothiazide (HCTZ) in the Han Chinese population with essential hypertension. We enrolled 829 mild/moderate hypertensive patients and 12.5 mg of HCTZ was given daily. After 6 weeks, the results showed that the ACE I/D polymorphism, not the CYP11B2 -344T/C polymorphism, was associated with systolic blood pressure (SBP) response to HCTZ (P = 0.009) in the Han Chinese population with essential hypertension, with no interaction.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Aged
  • Antihypertensive Agents / pharmacology
  • Antihypertensive Agents / therapeutic use
  • Asian People / ethnology
  • Asian People / genetics*
  • Blood Pressure / drug effects
  • Blood Pressure / physiology
  • China
  • Cytochrome P-450 CYP11B2 / genetics*
  • Epistasis, Genetic / genetics
  • Female
  • Genotype
  • Humans
  • Hydrochlorothiazide / pharmacology
  • Hydrochlorothiazide / therapeutic use*
  • Hypertension / drug therapy*
  • Hypertension / ethnology
  • Hypertension / genetics*
  • INDEL Mutation / genetics
  • Male
  • Middle Aged
  • Peptidyl-Dipeptidase A / genetics*
  • Pharmacogenetics
  • Polymorphism, Genetic / genetics*
  • Retrospective Studies
  • Treatment Outcome

Substances

  • Antihypertensive Agents
  • Hydrochlorothiazide
  • Cytochrome P-450 CYP11B2
  • Peptidyl-Dipeptidase A