New pathway links γ-secretase to inflammation and memory while sparing notch

Ann Neurol. 2011 Jan;69(1):5-7. doi: 10.1002/ana.22310.
No abstract available

Publication types

  • Editorial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Alanine / analogs & derivatives
  • Alanine / metabolism
  • Alanine / pharmacology
  • Alanine / therapeutic use
  • Alzheimer Disease / drug therapy
  • Alzheimer Disease / metabolism
  • Amyloid Precursor Protein Secretases / antagonists & inhibitors
  • Amyloid Precursor Protein Secretases / metabolism*
  • Animals
  • Azepines / metabolism
  • Azepines / pharmacology
  • Azepines / therapeutic use
  • CREB-Binding Protein / metabolism
  • Humans
  • Inflammation / metabolism*
  • Membrane Proteins / metabolism
  • Memory / physiology*
  • Mice
  • Receptors, Notch / metabolism
  • Signal Transduction

Substances

  • Azepines
  • Membrane Proteins
  • N2-((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-L-alaninamide
  • Receptors, Notch
  • CREB-Binding Protein
  • Crebbp protein, mouse
  • Amyloid Precursor Protein Secretases
  • Alanine