Automated symptom alerts reduce postoperative symptom severity after cancer surgery: a randomized controlled clinical trial

J Clin Oncol. 2011 Mar 10;29(8):994-1000. doi: 10.1200/JCO.2010.29.8315. Epub 2011 Jan 31.

Abstract

Purpose: Patients receiving cancer-related thoracotomy are highly symptomatic in the first weeks after surgery. This study examined whether at-home symptom monitoring plus feedback to clinicians about severe symptoms contributes to more effective postoperative symptom control.

Patients and methods: We enrolled 100 patients receiving thoracotomy for lung cancer or lung metastasis in a two-arm randomized controlled trial; 79 patients completed the study. After hospital discharge, patients rated symptoms twice weekly for 4 weeks via automated telephone calls. For intervention group patients, an e-mail alert was forwarded to the patient's clinical team for response if any of a subset of symptoms (pain, disturbed sleep, distress, shortness of breath, or constipation) reached a predetermined severity threshold. No alerts were generated for controls. Group differences in symptom threshold events were examined by generalized estimating equation modeling.

Results: The intervention group experienced greater reduction in symptom threshold events than did controls (19% v 8%, respectively) and a more rapid decline in symptom threshold events. The difference in average reduction in symptom interference between groups was -0.36 (SE, 0.078; P = .02). Clinicians responded to 84% of e-mail alerts. Both groups reported equally high satisfaction with the automated system and with postoperative symptom control.

Conclusion: Frequent symptom monitoring with alerts to clinicians when symptoms became moderate or severe reduced symptom severity during the 4 weeks after thoracic surgery. Methods of automated symptom monitoring and triage may improve symptom control after major cancer surgery. These results should be confirmed in a larger study.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Decision Support Systems, Clinical*
  • Dyspnea / diagnosis
  • Dyspnea / etiology
  • Electronic Mail
  • Female
  • Humans
  • Lung Neoplasms / pathology
  • Lung Neoplasms / secondary
  • Lung Neoplasms / surgery*
  • Male
  • Middle Aged
  • Pain, Postoperative / diagnosis
  • Pain, Postoperative / etiology
  • Patient Discharge*
  • Postoperative Care
  • Postoperative Complications / diagnosis*
  • Postoperative Complications / etiology
  • Reminder Systems*
  • Self Report*
  • Severity of Illness Index
  • Sleep Wake Disorders / diagnosis
  • Sleep Wake Disorders / etiology
  • Surveys and Questionnaires
  • Telemedicine / methods*
  • Telephone
  • Texas
  • Thoracotomy / adverse effects*
  • Time Factors
  • Treatment Outcome