Autonomic MC sets the metabolic tone

Chun-Xia Yi; Andries Kalsbeek; Matthias H Tschöp

doi:10.1016/j.cmet.2011.01.014

Autonomic MC sets the metabolic tone

Cell Metab. 2011 Feb 2;13(2):121-3. doi: 10.1016/j.cmet.2011.01.014.

Authors

Chun-Xia Yi¹, Andries Kalsbeek, Matthias H Tschöp

Affiliation

¹ Metabolic Disease Institute, Division of Endocrinology, Department of Medicine, University of Cincinnati, Cincinnati, OH 45226, USA.

PMID: 21284978
DOI: 10.1016/j.cmet.2011.01.014

Abstract

The CNS melanocortin (MC) and the autonomic nervous (ANS) system represent key regulators of energy homeostasis. In this issue, Rossi et al. (2011) dissect metabolic functions of MC4 receptors based on anatomic localization within the ANS by re-expressing MC4R subpopulations in cholinergic or brainstem neurons of MC4R-KO mice.

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