The effect of enprostil on duodeno-jejunal motility in man

Aliment Pharmacol Ther. 1990 Feb;4(1):73-81. doi: 10.1111/j.1365-2036.1990.tb00451.x.

Abstract

Motor changes could be involved in the pathogenesis of diarrhoea that complicates the treatment of ulcer disease by prostaglandins. Our aim was to assess the effect of enprostil, a synthetic analogue of PGE2, on duodeno-jejunal motility. During this randomized double-blind crossover study, two manometric recordings, each lasting 20 h (12.00-08.00 hours), were carried out during dosing with 35 micrograms enprostil b.d. or placebo (eight volunteers: part 1), or during dosing with 35 or 70 micrograms enprostil b.d. (nine volunteers: part 2). Subjects were only allowed a standard dinner at 18.00 hours. During fasting, in part 1, the number of phase 3 activity patterns (PIIIs) was higher with enprostil than with placebo (P less than 0.01), without any difference in their characteristics; the overall duration of phase 1 activity was longer with enprostil than with placebo (P less than 0.01). In part 2, during fasting the number and characteristics of the PIIIs were not different, but there was a dose-related increase in PI, and decrease in PII activity. Fed motor patterns did not differ between the two doses of enprostil.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Duodenum / drug effects
  • Duodenum / physiology*
  • Enprostil
  • Food
  • Gastrointestinal Motility / drug effects*
  • Humans
  • Jejunum / drug effects
  • Jejunum / physiology*
  • Male
  • Prostaglandins E, Synthetic / adverse effects
  • Prostaglandins E, Synthetic / pharmacology*

Substances

  • Prostaglandins E, Synthetic
  • Enprostil