Abstract
An activator protein-1 (AP-1) based bioassay-guided phytochemical investigation on Podocarpus latifolius led to the isolation of three new sempervirol-type diterpenes, cycloinumakiol (1), inumakal (2), and inumakoic acid (3), along with three known norditerpenes (4-6). Compounds 4 and 6 were responsible for the observed bioactivity.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, N.I.H., Intramural
MeSH terms
-
Diterpenes / chemistry
-
Diterpenes / isolation & purification*
-
Diterpenes / pharmacology*
-
Humans
-
Molecular Structure
-
Pinaceae / chemistry*
-
Plant Bark / chemistry
-
Plant Roots / chemistry
-
Tanzania
-
Transcription Factor AP-1 / antagonists & inhibitors*
Substances
-
11,10-oxymethylenecyclopent-14-isopropyl-8,11,13-podocarpatriene
-
11-hydroxy-14-isopropyl-8,11,13-podocarpatrien-19-al
-
11-hydroxy-14-isopropyl-8,11,13-podocarpatrien-19-oic acid
-
Diterpenes
-
Transcription Factor AP-1