Circadian clock gene Per3 variants influence the postpartum onset of bipolar disorder

S Dallaspezia; C Lorenzi; A Pirovano; C Colombo; E Smeraldi; F Benedetti

doi:10.1016/j.eurpsy.2010.11.009

Circadian clock gene Per3 variants influence the postpartum onset of bipolar disorder

Eur Psychiatry. 2011 Apr;26(3):138-40. doi: 10.1016/j.eurpsy.2010.11.009.

Authors

S Dallaspezia¹, C Lorenzi, A Pirovano, C Colombo, E Smeraldi, F Benedetti

Affiliation

¹ Department of Clinical Neurosciences, Scientific Institute and University Vita-Salute San Raffaele, Via Stamira d’Ancona 20, Milan, Italy. [email protected]

PMID: 21316201
DOI: 10.1016/j.eurpsy.2010.11.009

Abstract

Postpartum depression can mark the onset of bipolar disorder. The coding region of Per3 gene contains a variable-number tandem-repeat polymorphism, which has been shown to influence bipolar disorder onset and to affect breast cancer risk. We showed a relationship between Per3 polymorphism and postpartum depressive onset in bipolar disorder.

MeSH terms

Adult
Bipolar Disorder / genetics*
Depression, Postpartum / genetics*
Female
Genetic Predisposition to Disease
Genetic Variation
Humans
Period Circadian Proteins / genetics*
Polymorphism, Genetic
Postpartum Period / genetics*
Tandem Repeat Sequences

Substances

PER3 protein, human
Period Circadian Proteins