CD160: a unique activating NK cell receptor

Philippe Le Bouteiller; Julie Tabiasco; Beata Polgar; Noemi Kozma; Jérôme Giustiniani; Johan Siewiera; Alain Berrebi; Maryse Aguerre-Girr; Armand Bensussan; Nabila Jabrane-Ferrat

doi:10.1016/j.imlet.2011.02.003

CD160: a unique activating NK cell receptor

Immunol Lett. 2011 Aug 30;138(2):93-6. doi: 10.1016/j.imlet.2011.02.003. Epub 2011 Feb 13.

Authors

Philippe Le Bouteiller¹, Julie Tabiasco, Beata Polgar, Noemi Kozma, Jérôme Giustiniani, Johan Siewiera, Alain Berrebi, Maryse Aguerre-Girr, Armand Bensussan, Nabila Jabrane-Ferrat

Affiliation

¹ Institut National de la Santé et de la Recherche Médicale, UMR1043, Toulouse F-31300, France. [email protected]

PMID: 21324341
DOI: 10.1016/j.imlet.2011.02.003

Abstract

Here we discuss CD160 an essential NK cell activating receptor that remains poorly understood. CD160 receptor exhibits a number of unique structural and functional characteristics that are not common to other killer immunoglobulin-like receptors that recognize major histocompatibility complex (MHC) class I molecules: (1) In addition to humans and mice, the cd160 gene is conserved in several other mammal species; (2) cd160 is located outside the NK gene complex and the Leukocyte Receptor Complex in humans; (3) CD160 expression is associated to the CD56(dim) CD16+ cytotoxic NK cell phenotype; (4) both human and mouse CD160 recognize MHC class Ia and Ib molecules; (5) unlike the other MHC class I-dependent activating NK receptors, CD160 is a glycosylphosphatidylinositol-anchored molecule with a single immunoglobulin-like domain, and does not bear immunoreceptor tyrosine-based activation motifs. Consequently, CD160 cannot signal by itself, requiring the recruitment of adaptor proteins. CD160 recruits phosphoinositide-3 kinase to trigger cytotoxicity and cytokine secretion; (6) specific engagement of NK CD160 receptor expressed by circulating NK cells produces proinflammatory cytokines IFN-γ, TNF-α, and, most notably, IL-6 and IL-8 as well as MIP1-β chemokine. The level of CD160-mediated IFN-γ production is always higher than the one observed after engagement of the CD16 receptor.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

1-Phosphatidylinositol 4-Kinase / genetics
1-Phosphatidylinositol 4-Kinase / immunology
1-Phosphatidylinositol 4-Kinase / metabolism
Adaptor Proteins, Signal Transducing / genetics
Adaptor Proteins, Signal Transducing / immunology
Adaptor Proteins, Signal Transducing / metabolism
Amino Acid Motifs
Animals
Antigens, CD* / genetics
Antigens, CD* / immunology
Antigens, CD* / metabolism
CD56 Antigen / genetics
CD56 Antigen / immunology
CD56 Antigen / metabolism
Conserved Sequence
Cytokines / genetics
Cytokines / immunology
Cytokines / metabolism
Cytotoxicity, Immunologic*
GPI-Linked Proteins / genetics
GPI-Linked Proteins / immunology
GPI-Linked Proteins / metabolism
Gene Expression / immunology
Genes, MHC Class I / immunology
Glycosylphosphatidylinositols / genetics
Glycosylphosphatidylinositols / immunology
Glycosylphosphatidylinositols / metabolism
Humans
Killer Cells, Natural* / cytology
Killer Cells, Natural* / immunology
Killer Cells, Natural* / metabolism
Mice
Receptors, IgG / genetics
Receptors, IgG / immunology
Receptors, IgG / metabolism
Receptors, Immunologic* / genetics
Receptors, Immunologic* / immunology
Receptors, Immunologic* / metabolism
Signal Transduction / immunology*

Substances

Adaptor Proteins, Signal Transducing
Antigens, CD
CD160 protein, human
CD56 Antigen
Cytokines
GPI-Linked Proteins
Glycosylphosphatidylinositols
Receptors, IgG
Receptors, Immunologic
1-Phosphatidylinositol 4-Kinase