Abstract
The human Mediator complex interacts extensively with the RNA polymerase II (Pol II) enzyme and recent data from our lab suggest activator-induced structural shifts within Mediator trigger activation of stalled Pol II. These results are discussed together with other recent findings regarding post-recruitment regulation of Pol II.
Keywords:
CDK8; DSIF; Myc; NELF; P-TEFb; p53; review.
MeSH terms
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Humans
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Mediator Complex / chemistry
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Mediator Complex / metabolism*
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Mediator Complex Subunit 1 / chemistry
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Mediator Complex Subunit 1 / metabolism*
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Models, Genetic
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Mutation
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Promoter Regions, Genetic / genetics
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Protein Binding
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Protein Conformation
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Protein Subunits / chemistry
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Protein Subunits / metabolism
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RNA Polymerase II / metabolism*
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Trans-Activators
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Transcription, Genetic
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Tumor Suppressor Protein p53 / genetics
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Tumor Suppressor Protein p53 / metabolism*
Substances
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MED1 protein, human
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Med17 protein, human
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Mediator Complex
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Mediator Complex Subunit 1
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Protein Subunits
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Trans-Activators
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Tumor Suppressor Protein p53
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RNA Polymerase II