Antidotes to anthrax lethal factor intoxication. Part 2: structural modifications leading to improved in vivo efficacy

Bioorg Med Chem Lett. 2011 Apr 1;21(7):2030-3. doi: 10.1016/j.bmcl.2011.02.010. Epub 2011 Feb 18.

Abstract

New anthrax lethal factor inhibitors (LFIs) were designed based upon previously identified potent inhibitors 1a and 2. Combining the new core structures with modifications to the C2-side chain yielded analogs with improved efficacy in the rat lethal toxin model.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Antidotes / therapeutic use*
  • Antigens, Bacterial / poisoning*
  • Bacterial Toxins / poisoning*
  • Molecular Structure
  • Poisoning / drug therapy
  • Rats

Substances

  • Antidotes
  • Antigens, Bacterial
  • Bacterial Toxins
  • anthrax toxin