Outer membrane protein vesicle vaccines for meningococcal disease

C E Frasch; L van Alphen; J Holst; J T Poolman; E Rosenqvist

doi:10.1385/1-59259-148-5:81

Outer membrane protein vesicle vaccines for meningococcal disease

Methods Mol Med. 2001:66:81-107. doi: 10.1385/1-59259-148-5:81.

Authors

C E Frasch¹, L van Alphen, J Holst, J T Poolman, E Rosenqvist

Affiliation

¹ Division of Bacterial Products, Center for Biologics Evaluation and Research, Rockville, MD.

PMID: 21336749
DOI: 10.1385/1-59259-148-5:81

Abstract

Alternative strategies exist for prevention of group B Neisseria meningitidis (meningococcal) disease through vaccination (see Chapters 5 , 8 , 13 , 14 in this volume). However, the most promising approach to date has been the use of outer-membrane vesicle (OMV) vaccines for induction of bactericidal antibodies against cell-surface outer-membrane proteins (OMPs).