Abstract
Three novel triterpenoids, henrischinins A-C (1-3), featuring the unique motif of a 3-one-2-oxabicyclo[3.2.1]-octane, were isolated from the leaves and stems of Schisandra henryi. Their structures were elucidated by spectroscopic methods, and the absolute configuration of 2 was confirmed by a single crystal X-ray diffraction. Compounds 1 and 2 showed weak cytotoxicity against HL-60 cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Crystallography, X-Ray
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Drug Screening Assays, Antitumor
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HL-60 Cells
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Humans
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Molecular Conformation
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Molecular Structure
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Plant Leaves / chemistry
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Plant Stems / chemistry
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Schisandra / chemistry*
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology
Substances
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Antineoplastic Agents, Phytogenic
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Triterpenes
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henrischinin A
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henrischinin B
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henrischinin C