PAIRing for distal Igh locus V(D)J recombination

Chunguang Guo; Frederick W Alt; Cosmas Giallourakis

doi:10.1016/j.immuni.2011.02.010

PAIRing for distal Igh locus V(D)J recombination

Immunity. 2011 Feb 25;34(2):139-41. doi: 10.1016/j.immuni.2011.02.010.

Authors

Chunguang Guo¹, Frederick W Alt, Cosmas Giallourakis

Affiliation

¹ Howard Hughes Medical Institute, The Children's Hospital, The Immune Disease Institute, Department of Genetics, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.

PMID: 21349424
DOI: 10.1016/j.immuni.2011.02.010

Abstract

In this issue of Immunity Ebert et al. (2011) defined the lineage- and stage-specific Pax5-dependent cis-sequences termed PAIR elements in the distal region of the mouse heavy chain immunoglobulin locus (Igh). These sequences may have a role in long-range IgH V(D)J recombination.

Publication types

Comment

Grants and funding

R01 AI020047/AI/NIAID NIH HHS/United States