Hydroxyurea dose impacts hematologic parameters in polycythemia vera and essential thrombocythemia but does not appreciably affect JAK2-V617F allele burden

Haematologica. 2011 Mar;96(3):e18-20. doi: 10.3324/haematol.2010.037846.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Antineoplastic Agents / pharmacology
  • Dose-Response Relationship, Drug
  • Gene Frequency
  • Granulocytes / metabolism
  • Hematologic Tests
  • Humans
  • Hydroxyurea / pharmacology*
  • Janus Kinase 2 / genetics*
  • Janus Kinase 2 / metabolism
  • Point Mutation
  • Polycythemia Vera / blood*
  • Polycythemia Vera / drug therapy
  • Polycythemia Vera / enzymology
  • Polycythemia Vera / genetics*
  • Polymerase Chain Reaction
  • Retrospective Studies
  • Thrombocythemia, Essential / blood*
  • Thrombocythemia, Essential / drug therapy
  • Thrombocythemia, Essential / enzymology
  • Thrombocythemia, Essential / genetics*

Substances

  • Antineoplastic Agents
  • Janus Kinase 2
  • Hydroxyurea