Copper(II)-catalyzed ortho-functionalization of 2-arylpyridines with acyl chlorides

Chem Commun (Camb). 2011 Apr 7;47(13):3978-80. doi: 10.1039/c0cc05557c. Epub 2011 Feb 28.

Abstract

Copper-catalyzed ortho-benzoxylation of 2-arylpyridine sp(2) C-H bonds with acyl chloride is described. Notably, switching the base from t-BuOK to Li(2)CO(3) causes chlorination of the C-H bond to take place.