Somatostatin reduces neuropeptide Y rise induced by physical exercise

Horm Metab Res. 2011 May;43(5):361-3. doi: 10.1055/s-0031-1273681. Epub 2011 Mar 1.

Abstract

The effect of an i. v. infusion of somatostatin (SRIH) 4.1 μg/min×90 min on the basal secretion of NPY and on the NPY response to physical exercise was studied in normal men. Basal NPY secretion was not modified by SRIH infusion, whereas the NPY response to physical exercise was significantly lower in the presence of SRIH. These data suggest the involvement of a somatostatinergic mechanism in the regulation of NPY response to physical exercise.

MeSH terms

  • Adult
  • Down-Regulation
  • Exercise*
  • Humans
  • Infusions, Intravenous
  • Male
  • Neuropeptide Y / blood*
  • Somatostatin / administration & dosage
  • Somatostatin / metabolism*
  • Young Adult

Substances

  • Neuropeptide Y
  • Somatostatin