Fluorescent water soluble polymers for isozyme-selective interactions with matrix metalloproteinase-9

Bioorg Med Chem Lett. 2011 Apr 1;21(7):2007-10. doi: 10.1016/j.bmcl.2011.02.020. Epub 2011 Feb 28.

Abstract

Matrix metalloproteinases (MMPs) are overexpressed in various pathological conditions, including cancers. Although these isozymes have similar active sites, the patterns of exposed amino acids on their surfaces are different. Herein, we report the synthesis and molecular interactions of two water soluble, fluorescent polymers which demonstrate selective interactions with MMP-9 compared to MMP-7 and -10.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Fluorescent Dyes / chemistry*
  • Matrix Metalloproteinase 9 / chemistry*
  • Polymers / chemistry*
  • Solubility
  • Spectrometry, Fluorescence

Substances

  • Fluorescent Dyes
  • Polymers
  • Matrix Metalloproteinase 9