Abstract
Eight patients with inoperable advanced gastric cancer were treated with combination chemotherapy of S-1, low-dose cisplatin(CDDP)and Lentinan. S-1 80 mg/ m² was orally administered for 2 weeks followed by 1-week rest, CDDP 15 mg/ m² and Lentinan 2 mg/body were given intravenously on day 1 and 8. One complete response and four partial responses were observed for an overall response rate of 63%(5 of 8 patients). Only one patient developed over grade 3 toxicity leukocytopenia. Many patients could be maintained by long-term continuous treatment. Since combination chemotherapy of S-1/low-dose CDDP/Lentinan for advanced gastric cancer was very tolerable, it could be used for a long time.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Adult
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Aged
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Cisplatin / administration & dosage
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Cisplatin / adverse effects
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Cisplatin / therapeutic use*
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Drug Combinations
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Female
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Humans
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Lentinan / administration & dosage
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Lentinan / adverse effects
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Lentinan / therapeutic use*
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Male
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Middle Aged
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Neoplasm Staging
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Oxonic Acid / administration & dosage
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Oxonic Acid / adverse effects
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Oxonic Acid / therapeutic use*
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Stomach Neoplasms / drug therapy*
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Stomach Neoplasms / pathology
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Tegafur / administration & dosage
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Tegafur / adverse effects
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Tegafur / therapeutic use*
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Tomography, X-Ray Computed
Substances
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Drug Combinations
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S 1 (combination)
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Tegafur
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Lentinan
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Oxonic Acid
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Cisplatin