Synthesis and tautomerization of benzo[cd]azulen-3-ones

Org Lett. 2011 Apr 1;13(7):1670-3. doi: 10.1021/ol2001528. Epub 2011 Mar 3.

Abstract

This report describes a type of tautomerization reaction that proceeds via isomerization of π-bonds across the azulene moieties of tricyclic benzo[cd]azulen-3-ones. The reaction mechanism shows similarities to an elimination reaction that was recently developed in our group. Furthermore, the facile four-step syntheses of the benzo[cd]azulen-3-ones, the starting materials for the tautomerization reactions, and computational analyses of the tautomerization reaction are included.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Azulenes / chemical synthesis*
  • Benzene / chemistry*
  • Molecular Structure
  • Stereoisomerism

Substances

  • Azulenes
  • Benzene