Purpose: Hyperthermic intraperitoneal chemotherapy is continuously under evaluation in ovarian cancer. The purpose of the present study was to evaluate the effect of chemotherapy, drug concentration and temperature.
Materials and methods: A human ovarian carcinoma cell line was used. The effect of hyperthermia combined with chemotherapy was analyzed.
Results: When hyperthermia was combined with chemotherapy, the 50% lethal dose (LD(50)) decreased with the duration of exposure. The effect of temperature was similar between 39 and 43 °C for a 30-min exposure. For a 60- to 90-min exposure, the LD(50) was equivalent between 38 and 43 °C. Beyond 40 °C, an increase in platinum salt concentration was necessary to obtain similar results according to the duration of exposure.
Conclusions: The cytotoxic effect of the combination seemed to be potentiated and limited at 40 °C.
Copyright © 2011 S. Karger AG, Basel.