Luminescent, mesoporous, and bioactive europium-doped calcium silicate (MCS: Eu3+) as a drug carrier

J Colloid Interface Sci. 2011 May 15;357(2):280-5. doi: 10.1016/j.jcis.2011.01.109. Epub 2011 Mar 4.

Abstract

Luminescent, mesoporous, and bioactive europium-doped calcium silicate (MCS: Eu) was successfully synthesized. The obtained MCS: Eu(3+) was performed as a drug delivery carrier to investigate the drug storage/release properties using ibuprofen (IBU) as the model drug. The structural, morphological, textural, and optical properties were well characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), N(2) adsorption/desorption, and photoluminescence (PL) spectra, respectively. The results reveal that the MCS: Eu exhibits the typical ordered characteristics of the mesostructure. This composite shows a sustained release profile with IBU as the model drug. The IBU-loaded samples still present red luminescence of Eu(3+) ((5)D(0)-(7)F(1,2)) under UV irradiation. The emission intensities of Eu(3+) in the drug carrier system vary with the amount of released IBU, making the drug release easily tracked and monitored. The system demonstrates a great potential for drug delivery and disease therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Calcium / chemistry*
  • Drug Carriers / chemical synthesis
  • Drug Carriers / chemistry*
  • Europium / chemistry*
  • Ibuprofen / chemistry
  • Luminescence
  • Microscopy, Electron, Transmission
  • Porosity
  • Silicates / chemistry*
  • X-Ray Diffraction

Substances

  • Drug Carriers
  • Silicates
  • Europium
  • Calcium
  • Ibuprofen