Abstract
Fourteen new dibenzocyclooctadiene lignans, ananolignans A-N (1-14), together with five known compounds, were isolated from the seeds of Kadsura ananosma. The structures and absolute configurations of 1-14 were established using a combination of spectroscopic methods including 1D- and 2D-NMR and CD techniques. The biological activity of the isolated lignans was evaluated, and ananolignan F (6) and ananolignan L (12) showed significant neuroprotective effects in an in vitro assay.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cyclooctanes
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology*
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Kadsura / chemistry*
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Lignans / analysis
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Lignans / chemistry
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Molecular Structure
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Neuroprotective Agents / chemistry
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Neuroprotective Agents / isolation & purification*
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Neuroprotective Agents / pharmacology*
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Nuclear Magnetic Resonance, Biomolecular
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Seeds / chemistry
Substances
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Cyclooctanes
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Drugs, Chinese Herbal
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Lignans
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Neuroprotective Agents
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ananolignan F
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ananolignan L
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dibenzocyclooctadiene lignan