Persistence of yellow fever vaccine RNA in urine

Miguel J Martínez; Anna Vilella; Tomás Pumarola; Montserrat Roldan; Victor G Sequera; Isabel Vera; Edward B Hayes

doi:10.1016/j.vaccine.2011.02.075

Persistence of yellow fever vaccine RNA in urine

Vaccine. 2011 Apr 18;29(18):3374-6. doi: 10.1016/j.vaccine.2011.02.075. Epub 2011 Mar 6.

Authors

Miguel J Martínez¹, Anna Vilella, Tomás Pumarola, Montserrat Roldan, Victor G Sequera, Isabel Vera, Edward B Hayes

Affiliation

¹ Department of Clinical Microbiology, Hospital Clínic, Barcelona, Spain.

PMID: 21385635
DOI: 10.1016/j.vaccine.2011.02.075

Abstract

To evaluate possible persistence of 17D yellow fever vaccine, we tested urine samples from 44 healthy recipients of yellow fever vaccine at varying times up to one year after vaccination. Urine samples from two vaccine recipients had detectable yellow fever virus RNA. The time since vaccination was reported as 21 days for one sample and 198 days for the other sample. These results suggest that yellow fever vaccine virus might persist for at least 6 months after vaccination in some people.

MeSH terms

Adult
Female
Humans
Male
Middle Aged
RNA, Viral / chemistry
RNA, Viral / urine*
Sequence Analysis, RNA
Time Factors
Urine / chemistry
Urine / virology*
Vaccination
Viral Nonstructural Proteins / genetics
Yellow Fever Vaccine / urine*

Substances

NS5 protein, flavivirus
RNA, Viral
Viral Nonstructural Proteins
Yellow Fever Vaccine