Abstract
The predominant role of matrix metalloproteinase 8 in extracellular matrix turnover, modulation of inflammatory responses and other physiological processes is well documented. Several recent studies highlight the involvement of MMP8 in a wide range of pathologies. This review will shed light on the putative role of MMP8 as a drug target or disease marker in some inflammatory disorders and in cancer progression.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Arthritis, Rheumatoid / physiopathology
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Biomarkers / metabolism
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Cardiovascular Diseases / physiopathology*
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Diabetic Nephropathies / physiopathology
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Disease Progression
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Extracellular Matrix / physiology
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Eye Diseases / physiopathology
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Gastrointestinal Diseases / physiopathology
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Humans
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Inflammation / physiopathology*
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Liver Diseases / physiopathology
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Lung Diseases, Obstructive / physiopathology
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Malaria / physiopathology
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Matrix Metalloproteinase 8 / physiology*
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Neoplasms / pathology*
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Nervous System Diseases / physiopathology
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Periodontal Diseases / physiopathology
Substances
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Biomarkers
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Matrix Metalloproteinase 8