Subcutaneous linea alba fasciotomy (SLAF) is a minimally invasive treatment method for abdominal compartment syndrome initially used in severe acute pancreatitis (SAP). A retrospective analysis of the first 10 patients with SAP undergoing SLAF was performed to analyze the effect and outcome of this decompressive procedure. The mean age of the patients was 46 (range 33-61) years. SLAF was performed 1 to 17 days postadmission, in six cases within 48 hours. The mean (range) preoperative intra-abdominal pressure was 31 (23-45) mm Hg and immediate postoperative intra-abdominal pressure was 20 (10-33) mm Hg. The mean decrease was 10 (2-17) mm Hg and the decompressive effect was considered sufficient in six cases. A completion laparostomy within 24 hours was required in four cases. The mean preoperative Sequential Organ Failure Assessment score was 12 (4-17) and 11 (1-20) 1 to 5 days postoperatively. The decrease was five or more score points in three patients with successful SLAF. The overall mortality and morbidity rates were 4/10 and 2/10; no complications were attributed to the SLAF itself. It is concluded that SLAF is a safe decompressive technique in SAP-related abdominal compartment syndrome. The initial effect is sufficient in about half of the patients. A completion midline laparostomy is required in the nonresponders.