Prevalence and contributing factors of nonsusceptibility to imipenem or meropenem in extended-spectrum β-lactamase-producing Klebsiella pneumoniae and Escherichia coli

Yeon-Joon Park; Jin Kyung Yu; Kang Gyun Park; Yong Gyu Park; Seongok Lee; Soo-Young Kim; Seok Hoon Jeong

doi:10.1016/j.diagmicrobio.2010.12.012

Prevalence and contributing factors of nonsusceptibility to imipenem or meropenem in extended-spectrum β-lactamase-producing Klebsiella pneumoniae and Escherichia coli

Diagn Microbiol Infect Dis. 2011 Sep;71(1):87-9. doi: 10.1016/j.diagmicrobio.2010.12.012. Epub 2011 Mar 11.

Authors

Yeon-Joon Park¹, Jin Kyung Yu, Kang Gyun Park, Yong Gyu Park, Seongok Lee, Soo-Young Kim, Seok Hoon Jeong

Affiliation

¹ Department of Laboratory Medicine, School of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-ku, Seoul, 137-701, South Korea. [email protected]

PMID: 21397426
DOI: 10.1016/j.diagmicrobio.2010.12.012

Abstract

Among the extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae and Escherichia coli, 3.9% of K. pneumoniae showed nonsusceptibility to imipenem or meropenem; and their mechanism was the combination of ESBL and/or plasmid-mediated AmpC β-lactamase production and porin loss. The presence of bla(CTX-M-14) and loss of OmpK36 were associated with higher carbapenem MICs.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology*
Bacterial Proteins / genetics
Bacterial Proteins / metabolism
Drug Resistance, Bacterial / genetics
Escherichia coli / drug effects*
Escherichia coli / enzymology
Escherichia coli / genetics
Humans
Imipenem / pharmacology*
Klebsiella pneumoniae / drug effects*
Klebsiella pneumoniae / enzymology
Klebsiella pneumoniae / genetics
Meropenem
Microbial Sensitivity Tests
Porins / genetics
Porins / metabolism
Thienamycins / pharmacology*
beta-Lactamases / genetics
beta-Lactamases / metabolism*

Substances

Anti-Bacterial Agents
Bacterial Proteins
Porins
Thienamycins
Imipenem
beta-Lactamases
Meropenem