Synthetic approaches to monofluoroalkenes

Chem Soc Rev. 2011 May;40(5):2867-908. doi: 10.1039/c0cs00201a. Epub 2011 Mar 11.

Abstract

Monofluoroalkenes are an important fluorinated class of compounds with applications in medicinal chemistry, material sciences and organic chemistry. An overview of methods allowing synthetic access to these fluorinated building blocks is provided. In particular, this critical review, which covers publications up to October 2010, will be divided according to the substitution pattern of the monofluoroalkenes, i.e. di-, tri- or tetra-substituted. Within each group, the various synthetic approaches will be divided according to the reaction type (282 references).

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alkenes / chemical synthesis
  • Alkenes / chemistry*
  • Alkynes / chemistry
  • Fluorine / chemistry*
  • Halogenation
  • Safrole / analogs & derivatives
  • Safrole / chemistry
  • Sulfones / chemistry

Substances

  • Alkenes
  • Alkynes
  • Sulfones
  • Fluorine
  • Safrole
  • sulfoxide