Abstract
MAWI colonic cancer cells respond to sequential treatment in vitro with carboxypeptidase G2 and trimetrexate by a delay in cell growth as measured by cell numbers, but an increase in incorporation of 75-Se-selenomethionine per cell. The cells are not methionine auxotrophs.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / pharmacology*
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Carboxypeptidases / pharmacology*
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Cell Division / drug effects
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Colonic Neoplasms / pathology*
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Culture Media
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Homocysteine / pharmacology
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Humans
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Methionine / pharmacology
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Mice
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Quinazolines / pharmacology*
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Rabbits
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Trimetrexate
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Culture Media
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Quinazolines
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Homocysteine
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Methionine
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Carboxypeptidases
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Trimetrexate