Four new polyoxygenated gorgosterols from the gorgonian Isis hippuris

Mohammad Helal Uddin; Novriyandi Hanif; Agus Trianto; Yutaka Agarie; Tatsuo Higa; Junichi Tanaka

doi:10.1080/14786419.2010.485303

Four new polyoxygenated gorgosterols from the gorgonian Isis hippuris

Nat Prod Res. 2011 Mar;25(6):585-91. doi: 10.1080/14786419.2010.485303.

Authors

Mohammad Helal Uddin¹, Novriyandi Hanif, Agus Trianto, Yutaka Agarie, Tatsuo Higa, Junichi Tanaka

Affiliation

¹ Department of Chemistry, Biology and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan.

PMID: 21409719
DOI: 10.1080/14786419.2010.485303

Abstract

Four new polyoxygenated steroids (1-4) together with four known ones (5-8) have been isolated from the gorgonian Isis hippuris. The structures of the new compounds have been elucidated by spectroscopic analysis and chemical conversion. All of the new steroids showed moderate cytotoxicity against cultured NBT-T2 cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anthozoa / chemistry*
Cell Line
Cholesterol / analogs & derivatives*
Cholesterol / chemistry
Cholesterol / isolation & purification
Drug Screening Assays, Antitumor
Inhibitory Concentration 50
Molecular Structure
Rats

Substances

gorgosterol
Cholesterol