A new quinoline derivative with cytotoxic activity from Streptomyces sp. neau50

Xiang-Jing Wang; Dian-Liang Gong; Ji-Dong Wang; Ji Zhang; Chong-Xi Liu; Wen-Sheng Xiang

doi:10.1016/j.bmcl.2011.02.095

A new quinoline derivative with cytotoxic activity from Streptomyces sp. neau50

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2313-5. doi: 10.1016/j.bmcl.2011.02.095. Epub 2011 Mar 14.

Authors

Xiang-Jing Wang¹, Dian-Liang Gong, Ji-Dong Wang, Ji Zhang, Chong-Xi Liu, Wen-Sheng Xiang

Affiliation

¹ School of Life Science, Northeast Agricultural University, Harbin 150030, China.

PMID: 21411320
DOI: 10.1016/j.bmcl.2011.02.095

Abstract

A new quinoline derivative, methyl 8-(3-methoxy-3-methylbutyl)-2-methylquinoline-4-carboxylate (1), was isolated from the endophytic strain Streptomyces sp. neau50, and the structure was elucidated by extensive spectroscopic analysis. Compound 1 showed cytotoxicity against human lung adenocarcinoma cell line A549 with an IC(50) value of 29.3 μg mL(-1).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemistry*
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / toxicity
Cell Line, Tumor
Humans
Magnetic Resonance Spectroscopy
Molecular Conformation
Quinolines / chemistry*
Quinolines / isolation & purification
Quinolines / toxicity
Streptomyces / chemistry*

Substances

Antineoplastic Agents
Quinolines
methyl 8-(3-methoxy-3-methylbutyl)-2-methylquinoline-4-carboxylate
quinoline