We report a rare case of prolactinoma with deposition of amyloid and calcifications. Magnetic resonance imaging and/or computed tomography findings have been described in only a few cases. Possible mechanisms of amyloid deposition and calcification were discussed, and literatures were reviewed. In pituitary adenomas, particularly in prolactinomas, amyloid deposits should be included in the differential diagnosis, when hypointense areas are noted on T2-weighted images. Stippled calcifications in the tumor seem to be another characteristic finding.