Embryo implantation is a complex process regulated by an intimate cross-talk between the activated blastocysts and the receptive uterus. Under the synergetic interaction of E2 and P4, adhesion molecules, cytokines and growth factors are spatiotemporally expressed in the uterus during embryo implantation. The coordination between different signaling pathways is essential for embryo implantation. microRNAs are also involved in the regulation of embryo implantation. The main purpose of this paper is to summarize the progress on the signaling pathways participated in embryo implantation.