Detecting disease outbreaks using local spatiotemporal methods

Biometrics. 2011 Dec;67(4):1508-17. doi: 10.1111/j.1541-0420.2011.01585.x. Epub 2011 Mar 18.

Abstract

A real-time surveillance method is developed with emphasis on rapid and accurate detection of emerging outbreaks. We develop a model with relatively weak assumptions regarding the latent processes generating the observed data, ensuring a robust prediction of the spatiotemporal incidence surface. Estimation occurs via a local linear fitting combined with day-of-week effects, where spatial smoothing is handled by a novel distance metric that adjusts for population density. Detection of emerging outbreaks is carried out via residual analysis. Both daily residuals and AR model-based detrended residuals are used for detecting abnormalities in the data given that either a large daily residual or an increasing temporal trend in the residuals signals a potential outbreak, with the threshold for statistical significance determined using a resampling approach.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Data Interpretation, Statistical*
  • Disease Outbreaks / statistics & numerical data*
  • Humans
  • Incidence
  • Population Surveillance / methods*
  • Proportional Hazards Models*
  • Risk Assessment / methods
  • Risk Factors