Abstract
The adenovirus E1a protein (E1a), a potent transcription activator, contains a transcriptional activating region. Compared with previously described cellular and viral activators, E1a's activating region has unusual structural properties. It seems that E1a's activating region interacts with a cellular target not required for the function of transcriptional activators with 'acidic' activating regions. By contrast, the target of an acidic activating region is required both by acidic activators and by E1a. It is proposed that the cellular target of E1a's activating region is an 'adaptor' that allows E1a to interact with the basic transcriptional machinery.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adenovirus Early Proteins
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Amino Acid Sequence
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DNA Mutational Analysis
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DNA-Binding Proteins / physiology*
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Fungal Proteins / metabolism
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In Vitro Techniques
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Molecular Sequence Data
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Oncogene Proteins, Viral / physiology*
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Phosphoproteins / physiology
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Recombinant Fusion Proteins
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Saccharomyces cerevisiae Proteins*
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Structure-Activity Relationship
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Trans-Activators / physiology
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Transcription Factors / physiology*
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Transcription, Genetic*
Substances
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Adenovirus Early Proteins
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DNA-Binding Proteins
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Fungal Proteins
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GAL4 protein, S cerevisiae
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Oncogene Proteins, Viral
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Phosphoproteins
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Recombinant Fusion Proteins
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Saccharomyces cerevisiae Proteins
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Trans-Activators
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Transcription Factors