Abstract
Genetic down-regulation of a major nutrient-sensing pathway, TOR (target of rapamycin) signalling, can improve health and extend lifespan in evolutionarily distant organisms such as yeast and mammals. Recently, it has been demonstrated that treatment with a pharmacological inhibitor of the TOR pathway, rapamycin, can replicate those findings and improve aging in a variety of model organisms. The proposed underlying anti-aging mechanisms are down-regulated translation, increased autophagy, altered metabolism and increased stress resistance.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Down-Regulation / drug effects
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Down-Regulation / genetics
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Genetic Techniques*
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Genetic Therapy / methods
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Health*
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Humans
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Longevity* / drug effects
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Longevity* / physiology
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Models, Biological
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Pharmaceutical Preparations
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Protein Kinase Inhibitors / pharmacology
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Protein Kinase Inhibitors / therapeutic use*
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Signal Transduction / drug effects
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Signal Transduction / genetics
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TOR Serine-Threonine Kinases / antagonists & inhibitors*
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TOR Serine-Threonine Kinases / genetics*
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TOR Serine-Threonine Kinases / metabolism
Substances
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Pharmaceutical Preparations
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Protein Kinase Inhibitors
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MTOR protein, human
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TOR Serine-Threonine Kinases