Design, synthesis, and insecticidal evaluation of new benzoylureas containing isoxazoline and isoxazole group

J Agric Food Chem. 2011 May 11;59(9):4851-9. doi: 10.1021/jf200395g. Epub 2011 Mar 25.

Abstract

Twenty-two new benzoylphenylureas containing isoxazoline and the isoxazole group were designed and synthesized, and their structures were characterized by (1)H NMR and elemental analysis (or HRMS). The larvicidal activities against Oriental armyworm, mosquito, and diamondback moth of the new compounds were evaluated. Compounds I-1 and III-1 showed nearly the same level of insecticidal activity against Oriental armyworm as commercial insecticide Flucycloxuron and surprisingly exhibited much higher larvicidal activities against diamondback moth than Flucycloxuron.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Culicidae / drug effects
  • Drug Design
  • Insecticides / chemical synthesis*
  • Insecticides / chemistry
  • Insecticides / pharmacology*
  • Isoxazoles / chemical synthesis*
  • Isoxazoles / chemistry
  • Isoxazoles / pharmacology*
  • Moths / drug effects
  • Structure-Activity Relationship
  • Urea / chemical synthesis*
  • Urea / chemistry
  • Urea / pharmacology*

Substances

  • Insecticides
  • Isoxazoles
  • Urea