Abstract
MLL1 is a histone H3Lys4 methyltransferase and forms a complex with WDR5 and other components. It plays important roles in developmental events, transcriptional regulation, and leukemogenesis. MLL1-fusion proteins resulting from chromosomal translocations are molecular hallmarks of a special type of leukemia, which occurs in over 70% infant leukemia patients and often accompanies poor prognosis. Investigations in the past years on leukemogenesis and the MLL1-WDR5 histone H3Lys4 methyltransferase complex demonstrate that epigenetic regulation is one of the key steps in development and human diseases.
MeSH terms
-
Animals
-
DNA Methylation
-
Epigenesis, Genetic
-
Histone-Lysine N-Methyltransferase / genetics*
-
Histone-Lysine N-Methyltransferase / metabolism
-
Histones / metabolism
-
Humans
-
Intracellular Signaling Peptides and Proteins
-
Leukemia / genetics*
-
Leukemia / metabolism
-
Lysine / metabolism
-
Multiprotein Complexes / genetics
-
Multiprotein Complexes / metabolism
-
Myeloid-Lymphoid Leukemia Protein / genetics*
-
Myeloid-Lymphoid Leukemia Protein / metabolism
-
Transcriptional Activation
Substances
-
Histones
-
Intracellular Signaling Peptides and Proteins
-
KMT2A protein, human
-
Multiprotein Complexes
-
WDR5 protein, human
-
Myeloid-Lymphoid Leukemia Protein
-
Histone-Lysine N-Methyltransferase
-
Lysine