Monitoring the aggregation processes of amyloid-β using a spin-labeled, fluorescent nitroxyl radical

Chem Commun (Camb). 2011 May 7;47(17):5070-2. doi: 10.1039/c0cc05764a. Epub 2011 Mar 25.

Abstract

Amyloid nitroxyl radical (nitroxide) ligands were used to detect amyloid-β fibrils, the main constituents of senile plaques in Alzheimer's disease, using anisotropic ESR spectra, and were found to affect the aggregation process due to the radical functionality. These compounds have great potential as novel and multifunctional probes, combining spin labels, spin probes, and fluorescence probes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / diagnosis
  • Alzheimer Disease / metabolism
  • Alzheimer Disease / pathology
  • Amyloid / analysis*
  • Amyloid / metabolism
  • Amyloid beta-Peptides / analysis*
  • Amyloid beta-Peptides / metabolism
  • Benzothiazoles
  • Electron Spin Resonance Spectroscopy
  • Fluorescent Dyes / analysis*
  • Fluorescent Dyes / chemical synthesis
  • Humans
  • Nitrogen Oxides / analysis*
  • Nitrogen Oxides / chemical synthesis
  • Oxidation-Reduction
  • Spectrometry, Fluorescence
  • Spin Labels / chemical synthesis
  • Thiazoles / analysis

Substances

  • Amyloid
  • Amyloid beta-Peptides
  • Benzothiazoles
  • Fluorescent Dyes
  • Nitrogen Oxides
  • Spin Labels
  • Thiazoles
  • thioflavin T
  • nitroxyl