Abstract
Three new compounds, ferruginenes A (1) and B (2) and a mixture of C-5'(R) and C-5'(S) ferruginene C (3) diastereomers, have been isolated from a cytotoxic chloroform-soluble fraction of the leaves of Rhododendron ferrugineum together with 12 known compounds. The structures of these new compounds were elucidated by analyses of NMR spectroscopic and mass spectrometric data. Compounds 1-3 were tested for their cytotoxicity against three human cancer cell lines, namely, HL-60, HeLa-S3, and MCF-7.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Austria
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Biphenyl Compounds / chemistry
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Biphenyl Compounds / isolation & purification*
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Biphenyl Compounds / pharmacology*
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Drug Screening Assays, Antitumor
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HL-60 Cells
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HeLa Cells
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Heterocyclic Compounds, 3-Ring / chemistry
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Heterocyclic Compounds, 3-Ring / isolation & purification*
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Heterocyclic Compounds, 3-Ring / pharmacology*
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Humans
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Molecular Structure
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Plant Leaves / chemistry
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Rhododendron / chemistry
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Stereoisomerism
Substances
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Antineoplastic Agents, Phytogenic
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Biphenyl Compounds
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Heterocyclic Compounds, 3-Ring
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ferruginene A
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ferruginene B
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ferruginene C