Rhenium(IV) compounds inducing apoptosis in cancer cells

Chem Commun (Camb). 2011 May 14;47(18):5283-5. doi: 10.1039/c1cc11038a. Epub 2011 Mar 29.

Abstract

The anticancer properties of a series of mononuclear Re(IV) compounds of formula ReCl(4)L (where L is bpy = 2,2'-bipyridine; bpym = 2,2'-bipyrimidine; dmbpy = 4,4'-dimethyl-2,2'-bipyridine; phen = 1,10-phenanthroline) were investigated for the first time. All compounds displayed potent in vitro antiproliferative activity against selected cancer cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2,2'-Dipyridyl / chemistry*
  • 2,2'-Dipyridyl / pharmacology*
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology*
  • Apoptosis / drug effects*
  • Cell Line, Tumor / drug effects*
  • Humans
  • Ligands
  • Molecular Structure
  • Organometallic Compounds / chemistry*
  • Organometallic Compounds / pharmacology*
  • Phenanthrolines / chemistry*
  • Phenanthrolines / pharmacology*
  • Pyridines / chemistry*
  • Pyridines / pharmacology*
  • Rhenium / chemistry*

Substances

  • 4,4'-dimethyl-2,2'-bipyridine
  • Antineoplastic Agents
  • Ligands
  • Organometallic Compounds
  • Phenanthrolines
  • Pyridines
  • 2,2'-Dipyridyl
  • Rhenium
  • 1,10-phenanthroline