Hidradenitis suppurativa is a chronic, recurrent, debilitating disease that presents with inflamed lesions in the apocrine glands of the body. The most common locations are the axillary, inguinal and anogenital areas. Hidradenitis suppurativa is caused primarily by follicular occlusion with secondary involvement of the apocrine glands. The authors report a case of 47-old-man with an 18-year history of multiple sclerosis complicated by spastic paraparesis, who presented with hidradenitis suppurativa in the inguinal, perineal, and scrotal areas which was treated by wide surgical excision. A review of the most recent literature is included