Corticosteroids in severe community-acquired pneumonia: the path we choose depends on where we want to get

Crit Care. 2011;15(2):137. doi: 10.1186/cc10099. Epub 2011 Mar 24.

Abstract

Severe community-acquired pneumonia is a major cause of admission to intensive care units and its mortality rates remain exceedingly high. In the search for adjunctive therapies, clinicians who were encouraged by available, though limited, evidence prescribed steroids in most patients with severe sepsis or septic shock, including those with community-acquired pneumonia. Current evidence demonstrates that, whereas corticosteroids should not be routinely employed as adjuvant therapy for severe community-acquired pneumonia, there is sufficient equipoise to continue studying the use of corticosteroids.

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use*
  • Community-Acquired Infections / drug therapy*
  • Evidence-Based Medicine
  • Humans
  • Methylprednisolone / therapeutic use
  • Pneumonia / drug therapy*
  • Therapeutic Equipoise

Substances

  • Adrenal Cortex Hormones
  • Methylprednisolone