Abstract
The identification of targets which are located intracellularly in normal cells and are exposed on the surface of malignant cells is an issue in the target selection process for the development of anticancer agents. Targets with these characteristics should increase the specificity of intervention and the corresponding therapeutic window. We discuss targets such as heat-shock protein 70 (HSP70) and heat-shock protein 90 (HSP90), glucose-regulated protein 78 (GRP78), actin, cytokeratins, vimentin, nucleolin, nucleosomes, estrogen receptor-alpha variant 36 (ER-α36) and feto-acinar pancreatic protein (FAPP). Involvement of these targets in cellular processes, tumor specificity and tractability with antibody-related agents, are discussed.
MeSH terms
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Antibodies / immunology
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Antibodies / therapeutic use*
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Cell Membrane / metabolism*
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Endoplasmic Reticulum Chaperone BiP
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Estrogen Receptor alpha / genetics
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Estrogen Receptor alpha / immunology
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Estrogen Receptor alpha / metabolism
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HSP70 Heat-Shock Proteins / genetics
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HSP70 Heat-Shock Proteins / immunology
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HSP70 Heat-Shock Proteins / metabolism
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HSP90 Heat-Shock Proteins / genetics
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HSP90 Heat-Shock Proteins / immunology
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HSP90 Heat-Shock Proteins / metabolism
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Heat-Shock Proteins / genetics
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Heat-Shock Proteins / immunology
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Heat-Shock Proteins / metabolism
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Humans
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Models, Biological
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Neoplasms / drug therapy*
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Neoplasms / metabolism
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Neoplasms / pathology
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Proteins / genetics
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Proteins / immunology
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Proteins / metabolism*
Substances
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Antibodies
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ESR1 protein, human
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Endoplasmic Reticulum Chaperone BiP
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Estrogen Receptor alpha
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HSP70 Heat-Shock Proteins
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HSP90 Heat-Shock Proteins
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HSPA5 protein, human
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Heat-Shock Proteins
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Proteins