Abstract
The pharmacokinetics of oxaliplatin in plasma and ascitic fluid was investigated in 5 gastrointestinal cancer patients with malignant ascites. Oxaliplatin was administered at 85 mg/m² by 2-hour infusion in the FOLFOX4 regimen, and the concentrations of total and free platinum were measured. There was a trend of lower plasma C(max) values of total platinum in patients with a larger volume of ascitic fluid. The AUC(0-t) values of mean concentration curves of total plasma platinum, total ascites platinum, free plasma platinum, and free ascites platinum were 31.15, 7.96, 4.93 and 2.93 mg•h/ml, respectively. The concentrations of free ascites platinum were similar to those of free plasma platinum at the last sampling time of 26 h in each patient. The decrease or disappearance of ascitic fluid was observed in 4 patients. These results suggest that oxaliplatin exerted a beneficial effect in gastrointestinal cancer patients with malignant ascites, even when administered intravenously.
MeSH terms
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Aged
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / blood
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Antineoplastic Combined Chemotherapy Protocols / pharmacokinetics*
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Area Under Curve
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Ascites / blood
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Ascites / metabolism
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Ascites / pathology
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Ascitic Fluid / metabolism
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Female
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Fluorouracil / administration & dosage
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Fluorouracil / blood
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Fluorouracil / pharmacokinetics
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Gastrointestinal Neoplasms / blood
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Gastrointestinal Neoplasms / drug therapy
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Gastrointestinal Neoplasms / metabolism*
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Gastrointestinal Neoplasms / pathology
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Humans
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Infusions, Intravenous
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Leucovorin / administration & dosage
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Leucovorin / blood
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Leucovorin / pharmacokinetics
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Male
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Middle Aged
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Organoplatinum Compounds / administration & dosage
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Organoplatinum Compounds / blood
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Organoplatinum Compounds / pharmacokinetics*
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Organoplatinum Compounds / therapeutic use
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Oxaliplatin
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Platinum / blood
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Platinum / pharmacokinetics
Substances
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Organoplatinum Compounds
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Oxaliplatin
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Platinum
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Leucovorin
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Fluorouracil