Abnormal embryonic heart rate pattern in early pregnancy associated with Down's syndrome

Hum Reprod. 1990 Oct;5(7):877-9. doi: 10.1093/oxfordjournals.humrep.a137201.

Abstract

The case history of a 35-year-old woman with a pregnancy following IVF treatment is presented. Transvaginal sonography revealed an abnormal pattern of the embryonic heart rate between 28 and 50 days following follicular aspiration. At term, a male infant with the characteristics of Down's syndrome was born. The diagnosis was confirmed by chromosome analysis. The implications of this observation are discussed.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Chorionic Gonadotropin / therapeutic use
  • Down Syndrome / diagnostic imaging
  • Down Syndrome / genetics
  • Down Syndrome / physiopathology*
  • Embryo Transfer
  • Female
  • Fertilization in Vitro*
  • Fetal Diseases / diagnostic imaging
  • Fetal Diseases / physiopathology*
  • Follicle Stimulating Hormone / therapeutic use
  • Gestational Age
  • Heart Rate, Fetal*
  • Humans
  • Infertility, Female / therapy
  • Karyotyping
  • Male
  • Menotropins / therapeutic use
  • Pregnancy
  • Ultrasonography

Substances

  • Chorionic Gonadotropin
  • Menotropins
  • Follicle Stimulating Hormone